Granule cell type cerebellar hypoplasia(GCCH)
Also known as: Cerebellar granule cell hypoplasia · Granular cell cerebellar hypoplasia · Kleinhirnhypoplasie vom Granulazelltyp · Cerebellar cortical degeneration
Overview
What it is
This is an extremely rare developmental disorder of the brain, specifically affecting the cerebellum, which controls balance and coordination. In this condition, a specific layer of brain cells called the granule cell layer fails to develop properly. Because this part of the brain is underdeveloped, the dog cannot coordinate its movements normally.
How it presents
Symptoms typically appear in puppies between two and six weeks of age as they begin to walk. Owners will notice a severe lack of coordination, an unsteady wobbling gait, and head or body tremors that worsen when the puppy tries to focus on a specific task.
Treatment
There is no cure for this condition, and because of the severe impact on quality of life, affected puppies are usually euthanized. Diagnostic costs, primarily for veterinary consultations and brain imaging like an MRI, typically range from 500 to 2,500 EUR.
How it's tested
Hüftgelenksdysplasie-Auswertung (HD-Röntgen) nach FCI(HD-FCI)
Primary testRadiographRöntgenaufnahme der Hüftgelenke unter Sedation, ausgewertet nach FCI-Standard (A-E). Standardpflicht bei den meisten VDH-Zuchtvereinen.
Issuing body: FCI
Result scheme: HD-FCI
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Granule cell type cerebellar hypoplasia?
This is an extremely rare developmental disorder of the brain, specifically affecting the cerebellum, which controls balance and coordination. In this condition, a specific layer of brain cells called the granule cell layer fails to develop properly. Because this part of the brain is underdeveloped, the dog cannot coordinate its movements normally.
How is Granule cell type cerebellar hypoplasia tested?
Tests currently in our database: Hüftgelenksdysplasie-Auswertung (HD-Röntgen) nach FCI, Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.