Catalase Deficiency (Beagle)(CAT)
Also known as: Acatalasemia · Acatalasia · Katalasemangel · Catalase Deficiency · Akatalasemie · …
Overview
What it is
Catalase deficiency is an inherited metabolic disorder where the dog's body lacks the catalase enzyme, which is responsible for breaking down harmful hydrogen peroxide. Without this enzyme, hydrogen peroxide builds up and causes oxidative stress, a form of chemical damage to cells. This tissue damage is most prominent in the dog's mouth and gums.
How it presents
Owners will typically notice severe, progressive gum inflammation, painful mouth ulcers, and loose teeth starting from a young age. Affected dogs often develop extremely bad breath and may hesitate to eat due to oral pain.
Treatment
The condition is incurable and requires lifelong, intensive dental hygiene, including regular professional cleanings and surgical tooth extractions. Managing this chronic condition and controlling pain typically costs between 1,500 and 6,000 EUR over the dog's lifetime.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Hypokatalasie DNA-Test(CAT)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im CAT-Gen, welche zu einem Mangel des Enzyms Katalase führt.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Catalase Deficiency (Beagle)?
Catalase deficiency is an inherited metabolic disorder where the dog's body lacks the catalase enzyme, which is responsible for breaking down harmful hydrogen peroxide. Without this enzyme, hydrogen peroxide builds up and causes oxidative stress, a form of chemical damage to cells. This tissue damage is most prominent in the dog's mouth and gums.
How is Catalase Deficiency (Beagle) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Hypokatalasie DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.