Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP)(JLPP)
Also known as: Juvenile Laryngeal Paralysis and Polyneuropathy · Laryngeal Paralysis-Polyneuropathy Complex · Neuronal Vacuolation and Spinocerebellar Degeneration · Neuronal vacuolation · Neurodegenerative vacuolar storage disease
Overview
What it is
Juvenile Laryngeal Paralysis and Polyneuropathy (JLPP) is an inherited neurological disorder affecting the nerves and muscles of the throat and limbs. A genetic mutation impairs the signals sent from the brain to the larynx (voice box) and peripheral nerves, leading to progressive paralysis. This makes it difficult for the dog to breathe, swallow, and control its movement.
How it presents
Symptoms typically appear in puppies between 10 and 15 weeks of age, starting with breathing difficulties, heavy panting, coughing while drinking, and a hoarse bark. As the disease progresses, owners will notice weakness and coordination loss in the hind legs, which eventually spreads to the front legs.
Treatment
There is no cure for this progressive condition, and management is limited to supportive care to keep the puppy comfortable. Owners can expect diagnostic and palliative care costs to range between 500 and 2,500 EUR, though most affected dogs are humanely euthanized at a young age.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP)?
Juvenile Laryngeal Paralysis and Polyneuropathy (JLPP) is an inherited neurological disorder affecting the nerves and muscles of the throat and limbs. A genetic mutation impairs the signals sent from the brain to the larynx (voice box) and peripheral nerves, leading to progressive paralysis. This makes it difficult for the dog to breathe, swallow, and control its movement.
How is Juvenile Laryngeal Paralysis & Polyneuropathy (JLPP) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Rottweiler.