Immunodeficiency, CARD9-related(CARD9)
Also known as: CARD9 deficiency · CARD9-Defizienz · Caspase recruitment domain-containing protein 9 deficiency · CARD9-related immunodeficiency · Familiäre CARD9-Defizienz · …
Overview
What it is
This is an inherited immune system disorder where a genetic defect impairs the CARD9 protein, preventing the body from effectively fighting off fungal pathogens and certain bacteria like Mycobacterium avium complex (MAC). Because the immune system cannot control these common environmental organisms, they can spread unchecked and cause severe damage to internal organs, bones, and skin.
How it presents
The condition typically becomes apparent in young dogs, presenting as chronic, slow-healing infections of the skin, bones, or internal organs. Owners may observe persistent fever, swollen lymph nodes, lethargy, and progressive weight loss.
Treatment
There is no cure, and affected dogs require lifelong, intensive medical management with specialized medications. This supportive care is costly, with typical lifetime treatment expenses ranging from €3,000 to €12,000, and the long-term prognosis remains poor.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Immunodeficiency, CARD9-related?
This is an inherited immune system disorder where a genetic defect impairs the CARD9 protein, preventing the body from effectively fighting off fungal pathogens and certain bacteria like Mycobacterium avium complex (MAC). Because the immune system cannot control these common environmental organisms, they can spread unchecked and cause severe damage to internal organs, bones, and skin.
How is Immunodeficiency, CARD9-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.