Ichthyosis, TGM1-related(ARCI)
Also known as: TGM1-Ichthyose · Autosomal Recessive Congenital Ichthyosis · Transglutaminase-1 Deficiency · Congenital Ichthyosis TGM1-related · Jack Russell Terrier Ichthyosis
Overview
What it is
This is an inherited skin disorder caused by a genetic mutation in the TGM1 gene, which produces an enzyme essential for building the skin's outer protective barrier. Without this functioning enzyme, the skin cannot retain moisture or shed dead cells properly, leading to severe and uncontrolled scaling. This condition is also known as lamellar ichthyosis.
How it presents
Owners will typically notice symptoms shortly after birth or during early puppyhood, characterized by large, dark, plate-like scales and extremely dry skin. The skin may also develop painful cracks or fissures that are highly prone to secondary bacterial infections.
Treatment
There is no cure for this condition, meaning affected dogs require lifelong daily management with specialized topical treatments, moisturizing rinses, and frequent veterinary monitoring. Managing this chronic skin disease is estimated to cost between 3,000 and 8,000 EUR over the dog's lifetime.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Ichthyosis, TGM1-related?
This is an inherited skin disorder caused by a genetic mutation in the TGM1 gene, which produces an enzyme essential for building the skin's outer protective barrier. Without this functioning enzyme, the skin cannot retain moisture or shed dead cells properly, leading to severe and uncontrolled scaling. This condition is also known as lamellar ichthyosis.
How is Ichthyosis, TGM1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.