Ichthyosis, PNPLA1-related(ICT)
Also known as: Golden Retriever Ichthyosis · PNPLA1-Ichthyose · Ichthyose Typ A · ICT-A · Congenital Ichthyosiform Erythroderma · …
Overview
What it is
This is an inherited skin disorder caused by a genetic mutation that disrupts how the outer layer of the skin forms and sheds. Specifically, it affects the skin's ability to produce essential fats that maintain the natural moisture barrier, leading to a buildup of dry, dead skin cells. This disruption in the normal shedding process results in thick, scaly skin.
How it presents
Symptoms typically appear during puppyhood, often within the first few months of life. Owners will notice large, dry, and sometimes dark scales on the dog's abdomen and body, accompanied by a dry, dull coat.
Treatment
The condition is incurable and requires lifelong management rather than a one-time cure. Regular treatment with specialized shampoos and moisturizing therapies is necessary, with lifetime costs typically ranging from 1,500 to 4,500 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Ichthyosis, PNPLA1-related?
This is an inherited skin disorder caused by a genetic mutation that disrupts how the outer layer of the skin forms and sheds. Specifically, it affects the skin's ability to produce essential fats that maintain the natural moisture barrier, leading to a buildup of dry, dead skin cells. This disruption in the normal shedding process results in thick, scaly skin.
How is Ichthyosis, PNPLA1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.