Ichthyosis, ASPRV1-related(ARCI)
Also known as: ASPRV1-associated ichthyosis · ASPRV1-Ichthyose · Congenital ichthyosis German Shepherd
Overview
What it is
This form of ichthyosis is an inherited skin disorder caused by a genetic mutation in the ASPRV1 gene, which is passed down in an autosomal-dominant pattern. This mutation disrupts the normal renewal and protective barrier function of the outer layer of the skin, known as the epidermis. Because the inheritance is dominant, a dog only needs to inherit one copy of the mutated gene from a single parent to develop the condition.
How it presents
Symptoms typically become visible in puppies or young dogs as large, dry, and often dark scales across the body. Owners will also notice rough skin and a higher susceptibility to secondary skin infections.
Treatment
There is no cure for this condition, meaning it requires lifelong management with specialized therapeutic shampoos and moisturizing products. The estimated lifetime cost for this supportive care ranges from 1,500 to 5,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Ichthyosis, ASPRV1-related?
This form of ichthyosis is an inherited skin disorder caused by a genetic mutation in the ASPRV1 gene, which is passed down in an autosomal-dominant pattern. This mutation disrupts the normal renewal and protective barrier function of the outer layer of the skin, known as the epidermis. Because the inheritance is dominant, a dog only needs to inherit one copy of the mutated gene from a single parent to develop the condition.
How is Ichthyosis, ASPRV1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.