Hypomyelination(HYM)
Also known as: Shaking Pup Syndrome · Zittersyndrom · Myelinmangelsyndrom · SPS · Shaking Pup Disease · …
Overview
What it is
This is an inherited neurological disorder affecting the central nervous system, where the protective myelin sheath that insulates nerve fibers fails to develop properly. Without this adequate insulation, nerve signals cannot travel efficiently between the brain and the body. This disruption leads to impaired coordination and involuntary muscle movements.
How it presents
Symptoms typically become noticeable in puppies around two weeks of age, characterized by pronounced full-body tremors and a lack of coordination. These tremors are usually most severe when the puppy is active or excited and may subside when they are resting.
Treatment
There is no cure for this condition, and management is supportive to help the dog navigate their mobility challenges. Depending on the severity and whether the dog's symptoms improve as they mature, supportive care costs typically range from 500 to 4000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Hypomyelinisierung (HYM) DNA-Test(HYM)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation für Hypomyelinisierung (z.B. beim Weimaraner im FNIP2-Gen) und ermöglicht den Nachweis von betroffenen Tieren und Anlageträgern.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Hypomyelination?
This is an inherited neurological disorder affecting the central nervous system, where the protective myelin sheath that insulates nerve fibers fails to develop properly. Without this adequate insulation, nerve signals cannot travel efficiently between the brain and the body. This disruption leads to impaired coordination and involuntary muscle movements.
How is Hypomyelination tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Hypomyelinisierung (HYM) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Bernese Mountain Dog, Chow Chow, English Springer Spaniel, Golden Retriever, Samoyed, Short-haired Weimaraner, Weimaraner, Weimaraner (Long-haired).