Polyneuropathy, hypomyelinating, SH3TC2-related(HMP)
Also known as: Congenital Hypomyelinating Polyneuropathy · HPN · Charcot-Marie-Tooth disease type 4C · CMT4C
Overview
What it is
This is an inherited disorder of the peripheral nervous system where the protective outer coating, known as the myelin sheath, of the nerve fibers does not develop properly. Without this insulation, the nerves cannot transmit signals effectively from the brain to the muscles. This leads to progressive muscle weakness and coordination issues.
How it presents
Owners typically notice gait abnormalities, weakness in the hind legs, and coordination problems starting when the dog is just a few weeks to months old. These symptoms gradually worsen over time and can eventually lead to paralysis.
Treatment
There is no cure for this progressive condition, so treatment focuses on lifelong supportive care, physical therapy, and mobility aids. Managing these ongoing needs typically costs between 1,500 and 7,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyneuropathy, hypomyelinating, SH3TC2-related?
This is an inherited disorder of the peripheral nervous system where the protective outer coating, known as the myelin sheath, of the nerve fibers does not develop properly. Without this insulation, the nerves cannot transmit signals effectively from the brain to the muscles. This leads to progressive muscle weakness and coordination issues.
How is Polyneuropathy, hypomyelinating, SH3TC2-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.