Polyneuropathy, hypomyelinating, MPZ-related(HMP)
Also known as: Congenital Hypomyelinating Polyneuropathy, MPZ-related · HPN-MPZ · HPN
Overview
What it is
This is an inherited disorder of the nervous system caused by a genetic defect that prevents the proper formation of myelin, which is the protective insulating sheath around nerve fibers. Without this insulation, the nerves cannot properly transmit electrical signals from the brain to the muscles.
How it presents
Symptoms typically appear in early puppyhood, starting around eight weeks of age. Owners will notice progressive muscle weakness, tremors, and coordination difficulties that worsen rapidly.
Treatment
There is no cure for this progressive condition, and supportive care is aimed at maintaining comfort. Diagnostic and palliative care costs typically range from 500 to 2500 EUR, though the severity of the disease often leads to early euthanasia.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyneuropathy, hypomyelinating, MPZ-related?
This is an inherited disorder of the nervous system caused by a genetic defect that prevents the proper formation of myelin, which is the protective insulating sheath around nerve fibers. Without this insulation, the nerves cannot properly transmit electrical signals from the brain to the muscles.
How is Polyneuropathy, hypomyelinating, MPZ-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.