Polyneuropathy, hypomyelinating, MTMR2-related(MTMR2-PN)
Also known as: MTMR2 polyneuropathy · Hypomyelinating polyneuropathy · Charcot-Marie-Tooth disease type 4B1-like · MTMR2-related neuropathy · Inherited polyneuropathy
Overview
What it is
This is an inherited nervous system disorder where the protective outer coating, called the myelin sheath, surrounding the nerves is improperly formed. Without this protective layer, the nerves cannot properly transmit electrical signals from the brain to the muscles. This disruption leads to progressive muscle weakness and coordination issues throughout the body.
How it presents
Owners will typically notice signs of muscle weakness, an uncoordinated or wobbly gait, and difficulty standing starting in early puppyhood. These symptoms gradually worsen over time and can eventually lead to an inability to walk.
Treatment
There is no cure for this progressive condition, and management focuses entirely on supportive care to maintain comfort. Lifelong supportive care and veterinary assessments typically cost between 1,000 and 5,000 EUR, though euthanasia is often considered early due to the severity of the disease.
How it's tested
MTMR2-Polyneuropathie DNA-Test(MTMR2-PN)
Primary testDNA testEin DNA-Test zum Nachweis der ursächlichen Mutation im MTMR2-Gen, die zu dieser schweren Form der hypomyelinisierenden Polyneuropathie führt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Polyneuropathy, hypomyelinating, MTMR2-related?
This is an inherited nervous system disorder where the protective outer coating, called the myelin sheath, surrounding the nerves is improperly formed. Without this protective layer, the nerves cannot properly transmit electrical signals from the brain to the muscles. This disruption leads to progressive muscle weakness and coordination issues throughout the body.
How is Polyneuropathy, hypomyelinating, MTMR2-related tested?
Tests currently in our database: MTMR2-Polyneuropathie DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.