Hypolipoproteinemia(HLP)
Also known as: Hypobetalipoproteinemia · Hypobetalipoproteinämie · Apolipoprotein B deficiency · APOB deficiency · Lipid malabsorption in Hovawarts
Overview
What it is
This inherited metabolic disorder affects the digestive system, preventing the body from properly absorbing and transporting dietary fats. It occurs because the dog lacks specific transport proteins needed to carry fats through the bloodstream. Without these proteins, the body cannot utilize essential fats and fat-soluble nutrients.
How it presents
Symptoms usually appear in puppies or young dogs. Owners will typically notice chronic, greasy diarrhea, a failure to gain weight, and slower physical development.
Treatment
The condition is incurable but can be managed long-term with a strict, lifelong low-fat diet and vitamin supplements. Lifetime management costs typically range from 1,000 to 4,000 EUR.
How it's tested
Hypolipoproteinämie (HLP) DNA-Test(HLP)
Primary testDNA testDer DNA-Test identifiziert die Mutation im APOB-Gen, welche für die gestörte Fettabsorption und den mangelhaften Lipidtransport verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Hypolipoproteinemia?
This inherited metabolic disorder affects the digestive system, preventing the body from properly absorbing and transporting dietary fats. It occurs because the dog lacks specific transport proteins needed to carry fats through the bloodstream. Without these proteins, the body cannot utilize essential fats and fat-soluble nutrients.
How is Hypolipoproteinemia tested?
Tests currently in our database: Hypolipoproteinämie (HLP) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.