Palmoplantar hyperkeratosis, DSG1-related(PPK)
Also known as: Palmoplantar keratoderma · DSG1-related hyperkeratosis · Footpad hyperkeratosis · Palmoplantare Keratose · Hereditary Footpad Hyperkeratosis (DSG1-related) · …
Overview
What it is
This is an inherited skin disorder caused by a genetic mutation that disrupts how skin cells bind to one another. Without proper cell adhesion, the outer layer of the skin becomes unstable, leading to an extreme thickening of the paw pads, a condition known as hyperkeratosis. This primarily affects the integrity of the dog's paw pads and skin barrier.
How it presents
Symptoms typically appear in puppies or young dogs, manifesting as thick, hard, and deeply cracked paw pads. Owners will notice the dog showing signs of pain, limping, or developing secondary infections in the cracks.
Treatment
This condition is incurable and requires lifelong, daily management to soften the pads and treat painful cracks. Lifetime costs for specialized topical treatments, protective boots, and veterinary care typically range from €10,000 to €30,000.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Palmoplantar hyperkeratosis, DSG1-related?
This is an inherited skin disorder caused by a genetic mutation that disrupts how skin cells bind to one another. Without proper cell adhesion, the outer layer of the skin becomes unstable, leading to an extreme thickening of the paw pads, a condition known as hyperkeratosis. This primarily affects the integrity of the dog's paw pads and skin barrier.
How is Palmoplantar hyperkeratosis, DSG1-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.