Hyperbiliverdinaemia
Also known as: Hyperbiliverdinemia · Green Jaundice · Biliverdin reductase deficiency · Grüner Ikterus · Biliverdinämie
Overview
What it is
This is a rare metabolic condition affecting the liver's enzyme system, caused by an inherited genetic deletion in the BLVRA gene. Without this functioning gene, the body cannot properly convert biliverdin, a green pigment produced during the normal breakdown of red blood cells. This leads to an abnormal buildup of the green pigment in the blood, a state known as hyperbiliverdinaemia.
How it presents
Owners will typically notice a distinct green discoloration of their dog's urine, which is often visible from puppyhood. In some cases, the dog's gums, skin, or the whites of their eyes may also show a greenish tint.
Treatment
There is no cure for this lifelong condition, but it is managed supportively with a specialized liver diet and regular veterinary check-ups. The typical cost for ongoing management and monitoring ranges from 500 to 3000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Hyperbiliverdinaemia?
This is a rare metabolic condition affecting the liver's enzyme system, caused by an inherited genetic deletion in the BLVRA gene. Without this functioning gene, the body cannot properly convert biliverdin, a green pigment produced during the normal breakdown of red blood cells. This leads to an abnormal buildup of the green pigment in the blood, a state known as hyperbiliverdinaemia.
How is Hyperbiliverdinaemia tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.