Hereditary myopathy - Labrador retriever/Bouviers des Flandres myopathy(CNM)
Also known as: Centronuclear Myopathy · Hereditary Myopathy of the Labrador Retriever · HMLR · Labrador-Myopathie · Zentronukleäre Myopathie · …
Overview
What it is
This is an inherited muscle disease affecting the skeletal muscles of Labrador Retrievers and Bouviers des Flandres. It is caused by a genetic defect that prevents muscle fibers from developing normally, leading to progressive muscle wasting where the muscles gradually shrink and weaken.
How it presents
Symptoms typically appear in puppies between 2 and 5 months of age. Owners will usually notice an unusual 'bunny-hopping' gait, general muscle weakness, and rapid fatigue that worsens with cold temperatures or stress.
Treatment
While the disease is incurable, it often stabilizes in adulthood. Lifelong supportive care, including physical therapy and specialized dietary management, is required and typically costs between €1,500 and €6,000.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Centronukleäre Myopathie (CNM) DNA-Test(CNM)
Primary testDNA testEin molekularbiologischer Gentest (PCR) zum Nachweis der kausalen Mutation im HACD1-Gen, die für die zentronukleäre Myopathie verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Hereditary myopathy - Labrador retriever/Bouviers des Flandres myopathy?
This is an inherited muscle disease affecting the skeletal muscles of Labrador Retrievers and Bouviers des Flandres. It is caused by a genetic defect that prevents muscle fibers from developing normally, leading to progressive muscle wasting where the muscles gradually shrink and weaken.
How is Hereditary myopathy - Labrador retriever/Bouviers des Flandres myopathy tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Centronukleäre Myopathie (CNM) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Aussiedor (Australian Shepherd x Labrador), Labrador Retriever.