X-linked Hereditary Nephritis (Samoyed)(XLHN)
Also known as: X-linked Hereditary Nephritis · Samoyed Hereditary Glomerulopathy · SHG · Alport-Syndrom beim Samojeden · Hereditäre Glomerulopathie der Samojeden · …
Overview
What it is
This is an inherited kidney disease that primarily affects Samoyeds due to a genetic defect on the X chromosome. This defect impairs the collagen structure in the kidney's filtering units, known as glomeruli, preventing them from properly filtering waste from the blood. Over time, this structural weakness leads to progressive and severe kidney damage.
How it presents
Affected male puppies typically begin showing signs between 3 and 6 months of age. Owners may notice increased thirst and urination, weight loss, poor growth, and vomiting as kidney function declines.
Treatment
There is no cure for this condition, and treatment focuses on managing symptoms to temporarily support kidney function. Lifelong supportive care, including special diets and medications, typically costs between 1,500 and 6,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
X-linked Hereditary Nephritis DNA-Test(XLN)
Primary testDNA testDer DNA-Test auf X-chromosomale hereditäre Nephritis (XLN) identifiziert die ursächliche Mutation im COL4A5-Gen, um betroffene Hunde sowie weibliche Anlageträgerinnen sicher zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is X-linked Hereditary Nephritis (Samoyed)?
This is an inherited kidney disease that primarily affects Samoyeds due to a genetic defect on the X chromosome. This defect impairs the collagen structure in the kidney's filtering units, known as glomeruli, preventing them from properly filtering waste from the blood. Over time, this structural weakness leads to progressive and severe kidney damage.
How is X-linked Hereditary Nephritis (Samoyed) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), X-linked Hereditary Nephritis DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.