Hereditary Nasal Parakeratosis(HNPK)
Also known as: Erbliche Nasen-Parakeratose · Nasal Parakeratosis · SUV39H2-Mutation · HNPK-Genmutation · Greyhound Nasal Parakeratosis · …
Overview
What it is
Hereditary Nasal Parakeratosis (HNPK) is an inherited skin disorder that affects the nose. It is caused by a genetic defect that disrupts keratinization, which is the natural process where skin cells mature and form a protective, moisture-retaining outer layer. Without this barrier, the skin on the nose becomes extremely dry, thick, and prone to damage.
How it presents
Symptoms usually appear between 6 months and 2 years of age, starting with grey or brown crusts forming on the nose. These crusts can develop into deep, painful cracks that may bleed or become infected.
Treatment
There is no permanent cure, but the condition can be managed successfully with lifelong, daily application of moisturizing ointments. Lifetime management costs, including topical treatments and occasional veterinary checkups, typically range from 1,000 to 3,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Hereditary Nasal Parakeratosis?
Hereditary Nasal Parakeratosis (HNPK) is an inherited skin disorder that affects the nose. It is caused by a genetic defect that disrupts keratinization, which is the natural process where skin cells mature and form a protective, moisture-retaining outer layer. Without this barrier, the skin on the nose becomes extremely dry, thick, and prone to damage.
How is Hereditary Nasal Parakeratosis tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Labradoodle, Labrador Retriever.