Height, IGF1-AS-associated body-size variation(IGF1-AS)
Also known as: IGF1-AS body size locus · Insulin-like Growth Factor 1 Antisense · Dog height gene variant · IGF1-associated size variation · Körpergrößen-Genvariante IGF1-AS
Overview
What it is
This genetic variation affects a non-coding antisense RNA molecule (IGF1-AS) that regulates the expression of Insulin-like Growth Factor 1, a key hormone controlling skeletal growth. This variation influences how much of the hormone is produced, directly impacting the development of the skeletal and muscular systems. It is a natural genetic regulator of physical stature rather than a disease or medical disorder.
How it presents
Owners will notice differences in the dog's overall height and skeletal size as they grow from puppyhood into adulthood. There are no symptoms of illness or physical discomfort, as this variation simply determines whether a dog will naturally be on the smaller or larger side of their breed's spectrum.
Treatment
Because this is a normal genetic variation influencing body size and not a medical condition, no treatment is required. There are no associated medical costs, resulting in an expected lifetime treatment cost of 0 EUR.
How it's tested
IGF1-AS Gentest (Körpergröße)(IGF1-AS)
Primary testDNA testEin Gentest analysiert die genetische Variation im Bereich des IGF1-AS-Gens, um die vererbbare Körpergröße und Schulterhöhe des Hundes zu bestimmen.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Height, IGF1-AS-associated body-size variation?
This genetic variation affects a non-coding antisense RNA molecule (IGF1-AS) that regulates the expression of Insulin-like Growth Factor 1, a key hormone controlling skeletal growth. This variation influences how much of the hormone is produced, directly impacting the development of the skeletal and muscular systems. It is a natural genetic regulator of physical stature rather than a disease or medical disorder.
How is Height, IGF1-AS-associated body-size variation tested?
Tests currently in our database: IGF1-AS Gentest (Körpergröße).
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.