GST-theta enzyme activity, GSTT1-like-related(GSTT1)
Also known as: Glutathione S-transferase theta 1 deficiency · GSTT1 deficiency · GST-theta deficiency · Glutathione S-transferase theta activity · GSTT1-like variant
Overview
What it is
This genetic variation reduces the activity of the GST-theta enzyme, which is part of the liver's metabolic system. This enzyme is responsible for breaking down and neutralizing environmental toxins and certain medications. Without fully functioning enzymes, the dog's body may process these substances more slowly than normal.
How it presents
Affected dogs typically show no outward symptoms in their daily lives. However, adverse reactions or signs of liver stress may become apparent at any age if the dog is exposed to specific medications or environmental toxins.
Treatment
There is no direct treatment to restore enzyme activity, so management focuses on avoiding known toxic triggers and carefully selecting medications. This lifelong preventative approach is highly effective and carries minimal costs, typically ranging from 0 to 500 EUR.
How it's tested
GST-theta enzyme activity (GSTT1-like) DNA-Test(GSTT1)
Primary testDNA testEin DNA-Test, der die genetische Variation im GSTT1-ähnlichen Gen identifiziert, welche für eine reduzierte Aktivität des Glutathion-S-Transferase-Theta-Enzyms verantwortlich ist.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is GST-theta enzyme activity, GSTT1-like-related?
This genetic variation reduces the activity of the GST-theta enzyme, which is part of the liver's metabolic system. This enzyme is responsible for breaking down and neutralizing environmental toxins and certain medications. Without fully functioning enzymes, the dog's body may process these substances more slowly than normal.
How is GST-theta enzyme activity, GSTT1-like-related tested?
Tests currently in our database: GST-theta enzyme activity (GSTT1-like) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.