Glucocorticoid resistance
Also known as: Glukokortikoid-Resistenz · Glucocorticoid Receptor Hyposensitivity · Cortisol Resistance · Chrousos Syndrome · Glucocorticoid Receptor Deficiency
Overview
What it is
Glucocorticoid resistance is a metabolic and hormonal disorder where the body's tissues cannot properly respond to cortisol, a vital hormone produced by the adrenal glands. Because the cells are insensitive to this hormone, the body struggles to regulate essential functions like metabolism and immune responses. This lack of response leads to a chemical imbalance, as the body often produces excess cortisol in an attempt to compensate.
How it presents
Owners typically notice symptoms starting at a young age, which can include chronic weakness, extreme fatigue, and persistent skin issues. Affected dogs may also suffer from recurring, difficult-to-treat inflammation throughout the body.
Treatment
While the condition is incurable, it can be managed with lifelong medication and regular veterinary monitoring. The lifetime cost of treatment and diagnostic blood tests typically ranges from 3,000 to 10,000 EUR.
How it's tested
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Glucocorticoid resistance?
Glucocorticoid resistance is a metabolic and hormonal disorder where the body's tissues cannot properly respond to cortisol, a vital hormone produced by the adrenal glands. Because the cells are insensitive to this hormone, the body struggles to regulate essential functions like metabolism and immune responses. This lack of response leads to a chemical imbalance, as the body often produces excess cortisol in an attempt to compensate.
How is Glucocorticoid resistance tested?
Various clinical and genetic tests are used depending on the breed and presentation.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.