Coat colour, phaeomelanin dilution, MFSD12-related
Also known as: Phaeomelanin dilution · Intensity locus · I-Locus · MFSD12 coat color modifier · Red dilution in dogs · …
Overview
What it is
This genetic variant affects the integumentary system, specifically the hair follicles, by altering how red pigment, known as phaeomelanin, is produced. A variation in the MFSD12 gene dilutes these red or yellow pigments into lighter shades like cream, sand, or white. This is a purely cosmetic coat color variation and does not impact the dog's physical health.
How it presents
The lighter coat color is visible from birth and remains constant throughout the dog's life. Owners will notice cream, sandy, or white hair in areas that would typically be red or yellow, with no changes to skin health or coat texture.
Treatment
No treatment is necessary as this is a harmless visual trait rather than a medical condition. There are no associated veterinary costs, with expected lifetime expenses of 0 EUR.
How it's tested
Cream Dilution DNA-Test(Cream)
Primary testDNA testEin Gentest zur Identifizierung der Mutation im MFSD12-Gen, die für die Aufhellung von rotem und gelbem Pigment zu Creme oder Weiß verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
MFSD12-Gentest (Phäomelanin-Verdünnung)(I-Lokus (MFSD12))
Primary testDNA testEin DNA-Test untersucht das MFSD12-Gen auf Mutationen, die zu einer Aufhellung des roten Pigments (Phäomelanin) im Fell führen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Coat colour, phaeomelanin dilution, MFSD12-related?
This genetic variant affects the integumentary system, specifically the hair follicles, by altering how red pigment, known as phaeomelanin, is produced. A variation in the MFSD12 gene dilutes these red or yellow pigments into lighter shades like cream, sand, or white. This is a purely cosmetic coat color variation and does not impact the dog's physical health.
How is Coat colour, phaeomelanin dilution, MFSD12-related tested?
Tests currently in our database: Cream Dilution DNA-Test, MFSD12-Gentest (Phäomelanin-Verdünnung).
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.