Fanconi syndrome, FAN1-related(FS)
Also known as: Fanconi-Syndrom · FAN1-associated Fanconi syndrome · Renal Fanconi Syndrome · Fanconi-Syndrom (FAN1) · Proximal renal tubulopathy
Overview
What it is
Fanconi syndrome (FAN1-related) is an inherited kidney disorder that affects the renal tubules, which are the tiny filtering tubes in the kidneys. Instead of reabsorbing essential nutrients like glucose, amino acids, and electrolytes back into the bloodstream, the kidneys malfunction and flush these vital substances out through the urine. This constant loss of nutrients leads to severe metabolic imbalances throughout the body.
How it presents
Owners typically notice symptoms when the dog is between 2 and 6 years of age. Common signs include excessive drinking, frequent urination, unexplained weight loss, and muscle weakness.
Treatment
While the condition is incurable, it can be managed lifelong with a strict, specialized diet and targeted electrolyte supplementation. Managing this chronic disease requires regular veterinary monitoring, with lifetime costs typically ranging from 4,000 to 12,000 EUR.
How it's tested
Fanconi-Syndrom (FAN1) DNA-Test(FS)
Primary testDNA testDer DNA-Test identifiziert die Mutation im FAN1-Gen, welche für das Fanconi-Syndrom verantwortlich ist, und ermöglicht den Nachweis von freien, Träger- und betroffenen Hunden.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Fanconi syndrome, FAN1-related?
Fanconi syndrome (FAN1-related) is an inherited kidney disorder that affects the renal tubules, which are the tiny filtering tubes in the kidneys. Instead of reabsorbing essential nutrients like glucose, amino acids, and electrolytes back into the bloodstream, the kidneys malfunction and flush these vital substances out through the urine. This constant loss of nutrients leads to severe metabolic imbalances throughout the body.
How is Fanconi syndrome, FAN1-related tested?
Tests currently in our database: Fanconi-Syndrom (FAN1) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.