Factor XII deficiency(FXIID)
Also known as: Faktor-XII-Mangel · Hageman factor deficiency · FXII deficiency · Factor 12 deficiency · Hageman-Faktor-Mangel
Overview
What it is
Factor XII deficiency is an inherited blood clotting disorder where the body lacks a specific protein called Factor XII, which normally helps initiate the coagulation process. This deficiency affects the circulatory system, specifically how blood behaves during laboratory testing. Despite its role in the clotting cascade, the lack of this protein does not impair normal blood clotting inside the living animal.
How it presents
This condition is completely asymptomatic, meaning affected dogs show no physical signs of illness or abnormal bleeding. It is present from birth and is typically discovered by chance at any age during routine pre-surgical blood tests that show a prolonged clotting time.
Treatment
No treatment is necessary because this condition is entirely benign and does not affect the dog's health or lifespan. There are no ongoing therapy costs, with expected lifetime expenses ranging from 0 to 150 EUR, which would only cover the initial diagnostic blood test.
How it's tested
Faktor-XII-Mangel DNA-Test(FXIID)
Primary testDNA testEin DNA-Test identifiziert die spezifische Mutation im F12-Gen, die für den Mangel an Gerinnungsfaktor XII verantwortlich ist.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Factor XII deficiency?
Factor XII deficiency is an inherited blood clotting disorder where the body lacks a specific protein called Factor XII, which normally helps initiate the coagulation process. This deficiency affects the circulatory system, specifically how blood behaves during laboratory testing. Despite its role in the clotting cascade, the lack of this protein does not impair normal blood clotting inside the living animal.
How is Factor XII deficiency tested?
Tests currently in our database: Faktor-XII-Mangel DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.