Factor X deficiency(FXD)
Also known as: Faktor-X-Mangel · Stuart-Prower-Faktor-Mangel · Stuart-Prower factor deficiency · Factor 10 deficiency · F10 deficiency
Overview
What it is
Factor X deficiency is an inherited blood clotting disorder affecting the circulatory system. It is caused by a lack of coagulation factor X, a crucial protein needed to form stable blood clots. Without enough of this protein, the body's secondary hemostasis—the chemical process that solidifies a temporary platelet plug into a stable clot—fails, leading to prolonged bleeding.
How it presents
Symptoms typically appear during puppyhood, often noticed during teething or after minor injuries. Owners may observe frequent nosebleeds, heavy gum bleeding, unexplained bruising under the skin, or prolonged bleeding after routine veterinary procedures.
Treatment
While the condition is lifelong and cannot be cured, it can be managed by avoiding trauma and using blood or plasma transfusions during bleeding crises. Lifetime management and emergency treatments typically cost between €1,500 and €6,000.
How it's tested
Faktor-X-Mangel DNA-Test(FXD)
Primary testDNA testEin DNA-Test zur Identifikation der Mutation im F10-Gen, die zu einem Mangel an Gerinnungsfaktor X und damit zu einer gestoerten Blutgerinnung fuehrt.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Factor X deficiency?
Factor X deficiency is an inherited blood clotting disorder affecting the circulatory system. It is caused by a lack of coagulation factor X, a crucial protein needed to form stable blood clots. Without enough of this protein, the body's secondary hemostasis—the chemical process that solidifies a temporary platelet plug into a stable clot—fails, leading to prolonged bleeding.
How is Factor X deficiency tested?
Tests currently in our database: Faktor-X-Mangel DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.