Dyserythropoietic anemia and myopathy syndrome(DAMS)
Also known as: Dyserythropoietic Anemia and Myopathy · Congenital dyserythropoietic anemia and myopathy · Labrador Retriever DAMS · Congenital dyserythropoietic anemia and polymyopathy
Overview
What it is
Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) is an inherited disorder caused by mutations in the EHBP1L1 gene in Labrador Retrievers and English Springer Spaniels. It simultaneously affects the blood-producing system and the muscles, leading to poorly formed red blood cells, known as anemia, and the progressive breakdown of skeletal muscle tissue. This dual impact means the dog's body cannot transport oxygen efficiently and their muscles gradually weaken.
How it presents
Symptoms typically appear in puppies between 6 and 14 weeks of age. Owners will usually notice pronounced weakness, pale gums, muscle wasting, and developmental delays or slow growth.
Treatment
This condition is incurable and progressive, with treatment limited to supportive care and diagnostics to keep the puppy comfortable before euthanasia is typically necessary. These palliative management steps generally cost between 500 and 2500 EUR.
How it's tested
Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) DNA-Test(DAMS)
Primary testDNA testDer DNA-Test identifiziert die ursächliche Mutation im PIGY-Gen beim Labrador Retriever, um betroffene Hunde und symptomfreie Anlageträger zuverlässig nachzuweisen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Dyserythropoietic anemia and myopathy syndrome?
Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) is an inherited disorder caused by mutations in the EHBP1L1 gene in Labrador Retrievers and English Springer Spaniels. It simultaneously affects the blood-producing system and the muscles, leading to poorly formed red blood cells, known as anemia, and the progressive breakdown of skeletal muscle tissue. This dual impact means the dog's body cannot transport oxygen efficiently and their muscles gradually weaken.
How is Dyserythropoietic anemia and myopathy syndrome tested?
Tests currently in our database: Dyserythropoietic Anemia and Myopathy Syndrome (DAMS) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.