Color Dilution Alopecia with neurological defects(GS)
Also known as: Griscelli Syndrome · Griscelli-like Syndrome · Dilute with neurological defects · MYO5A-associated neurological syndrome · Griscelli-Syndrom · …
Overview
What it is
This severe genetic disorder affects both the nervous system and pigment production, serving as the canine equivalent of human Griscelli Syndrome Type 1. It is caused by a mutation in the MYO5A gene, which disrupts how cells transport pigment and support normal nerve function. This dual impact results in a lighter coat color alongside progressive neurological decline.
How it presents
Affected puppies are born with a diluted coat color and typically develop severe neurological symptoms within their first few weeks of life. Owners will notice involuntary body tremors, seizures, and a significant lack of coordination when the puppy tries to move.
Treatment
This condition is currently incurable, and management is limited to diagnostic testing and palliative care, which typically costs between 300 and 1500 EUR. Due to the rapid and severe decline in quality of life, affected puppies are usually humanely euthanized.
How it's tested
Griscelli-Syndrom (GS) DNA-Test(GS)
Primary testDNA testEin Gentest identifiziert die Mutation im MYO5A-Gen, die für das Griscelli-Syndrom (Dilute-Fellfarbe mit neurologischen Defekten) verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Color Dilution Alopecia with neurological defects?
This severe genetic disorder affects both the nervous system and pigment production, serving as the canine equivalent of human Griscelli Syndrome Type 1. It is caused by a mutation in the MYO5A gene, which disrupts how cells transport pigment and support normal nerve function. This dual impact results in a lighter coat color alongside progressive neurological decline.
How is Color Dilution Alopecia with neurological defects tested?
Tests currently in our database: Griscelli-Syndrom (GS) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.