Dilated Cardiomyopathy, RBM20-related(DCM)
Also known as: RBM20-DCM · Dilated Cardiomyopathy RBM20-related · RBM20 dilated cardiomyopathy · Dilatative Kardiomyopathie RBM20 · RBM20-associated DCM · …
Overview
What it is
This is an inherited heart condition caused by a genetic mutation in the RBM20 gene, which leads to the progressive stretching and thinning of the heart muscle. Because the heart walls become thin and weak, the heart cannot pump blood effectively to the rest of the body. This eventually leads to congestive heart failure, where fluid builds up in the lungs or abdomen.
How it presents
Owners may notice their dog tiring quickly during exercise, coughing, having difficulty breathing, or fainting. These symptoms typically begin to appear in young to middle-aged adult dogs.
Treatment
While the condition is incurable, it can be managed with lifelong cardiac medications and regular veterinary heart scans. This ongoing care is estimated to cost between €3,000 and €10,000 over the dog's lifetime.
How it's tested
DCM DNA-Test (Dilatative Kardiomyopathie)(DCM)
Primary testDNA testDCM-assoziierte Mutation (z.B. PDK4 bei Dobermann). Mehrere Mutationen je nach Rasse.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Herzultraschall (Echokardiographie)(Herz-Echo)
Cardiac examEchokardiographie zur Beurteilung von Herzklappen, -wänden, -funktion. Pflicht z.B. bei Cavalier King Charles Spaniel (MMVD).
Issuing body: vet
Result scheme: Cardiac-OFA
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Dilated Cardiomyopathy, RBM20-related?
This is an inherited heart condition caused by a genetic mutation in the RBM20 gene, which leads to the progressive stretching and thinning of the heart muscle. Because the heart walls become thin and weak, the heart cannot pump blood effectively to the rest of the body. This eventually leads to congestive heart failure, where fluid builds up in the lungs or abdomen.
How is Dilated Cardiomyopathy, RBM20-related tested?
Tests currently in our database: DCM DNA-Test (Dilatative Kardiomyopathie), Herzultraschall (Echokardiographie), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.