Dilated Cardiomyopathy (DCM), PLN-related(DCM)
Also known as: Dilated Cardiomyopathy PLN-related · PLN-DCM · Phospholamban-associated Dilated Cardiomyopathy · Dilatative Kardiomyopathie PLN-Gen · PLN dilated cardiomyopathy · …
Overview
What it is
This is an inherited heart disease where a genetic mutation in the phospholamban (PLN) gene causes the heart muscle to become thin, stretched, and weak. As a result, the heart chambers enlarge and lose their ability to pump blood efficiently throughout the body. This progressive weakening eventually leads to heart failure.
How it presents
Owners typically notice signs like rapid tiring during exercise, coughing, breathing difficulties, or fainting, which usually develop in middle-aged to older dogs.
Treatment
The condition is incurable and requires lifelong daily cardiac medication and regular veterinary monitoring. Lifetime treatment and diagnostic costs typically range from €2,500 to €8,000.
How it's tested
DCM DNA-Test (Dilatative Kardiomyopathie)(DCM)
Primary testDNA testDCM-assoziierte Mutation (z.B. PDK4 bei Dobermann). Mehrere Mutationen je nach Rasse.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Herzultraschall (Echokardiographie)(Herz-Echo)
Cardiac examEchokardiographie zur Beurteilung von Herzklappen, -wänden, -funktion. Pflicht z.B. bei Cavalier King Charles Spaniel (MMVD).
Issuing body: vet
Result scheme: Cardiac-OFA
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
DNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Dilated Cardiomyopathy (DCM), PLN-related?
This is an inherited heart disease where a genetic mutation in the phospholamban (PLN) gene causes the heart muscle to become thin, stretched, and weak. As a result, the heart chambers enlarge and lose their ability to pump blood efficiently throughout the body. This progressive weakening eventually leads to heart failure.
How is Dilated Cardiomyopathy (DCM), PLN-related tested?
Tests currently in our database: DCM DNA-Test (Dilatative Kardiomyopathie), Herzultraschall (Echokardiographie), Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.