Degenerative encephalopathy, RB1CC1-related(DE)
Also known as: Degenerative Encephalopathy in Nova Scotia Duck Tolling Retrievers · DE-NSDTR · RB1CC1 degenerative encephalopathy · Degenerative Enzephalopathie beim Toller
Overview
What it is
This is an inherited neurological disorder caused by a genetic mutation in the RB1CC1 gene, which leads to the progressive breakdown of nerve cells in the brain. As these brain cells degenerate, the dog loses the ability to properly coordinate movements and regulate behavior.
How it presents
Owners typically notice symptoms starting between a few months and several years of age, beginning with unsteadiness on their feet. Over time, affected dogs may also develop sleep disturbances and noticeable behavioral changes, such as sudden anxiety or aggression.
Treatment
There is no cure for this progressive condition, and supportive care is aimed at managing symptoms. Veterinary costs for diagnostics and palliative care typically range from 1,000 to 3,000 EUR, and early euthanasia is often elected due to the severity of the decline.
How it's tested
Degenerative Enzephalopathie (DE) DNA-Test(DE)
Primary testDNA testEin DNA-Test, der die ursächliche Mutation im RB1CC1-Gen nachweist, um betroffene Hunde, Träger und mutationsfreie Tiere zu identifizieren.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Degenerative encephalopathy, RB1CC1-related?
This is an inherited neurological disorder caused by a genetic mutation in the RB1CC1 gene, which leads to the progressive breakdown of nerve cells in the brain. As these brain cells degenerate, the dog loses the ability to properly coordinate movements and regulate behavior.
How is Degenerative encephalopathy, RB1CC1-related tested?
Tests currently in our database: Degenerative Enzephalopathie (DE) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.