Degenerative encephalopathy(DE)
Also known as: Degenerative Encephalopathy with Sleep Chokings · DE-NSDTR · Degenerative Enzephalopathie · Encephalopathy in Tollers · RB1CC1-associated degenerative encephalopathy · …
Overview
What it is
Degenerative encephalopathy is a severe, inherited brain disorder caused by a genetic mutation in the RB1CC1 gene. This mutation leads to the progressive breakdown of nerve tissue in the brain, which severely disrupts how signals are transmitted throughout the central nervous system.
How it presents
Symptoms typically begin to appear when a dog is between 3 and 5 years old. Owners may notice movement difficulties, behavioral changes like sudden aggression, and unusual choking or gasping spells while the dog is asleep.
Treatment
There is no cure for this progressive condition, and veterinary care focuses on supportive measures to manage symptoms. Lifetime palliative care typically costs between €1,000 and €4,000.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Degenerative encephalopathy?
Degenerative encephalopathy is a severe, inherited brain disorder caused by a genetic mutation in the RB1CC1 gene. This mutation leads to the progressive breakdown of nerve tissue in the brain, which severely disrupts how signals are transmitted throughout the central nervous system.
How is Degenerative encephalopathy tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Nova Scotia Duck Tolling Retriever.