Cystinuria Type 3 Variant 2 risk factor(Cyst3-2)
Also known as: Cystinuria Type III Variant 2 · Type 3 Cystinuria · Androgen-dependent cystinuria · Cystinurie Typ 3 · Cystinurie Typ III Variante 2 · …
Overview
What it is
This is an inherited metabolic disorder of the kidneys where the organ fails to properly reabsorb the amino acid cystine from the urine. Excess cystine then builds up and forms painful crystals or stones in the bladder and urinary tract. This specific Type 3 variant is complex and influenced by hormones, primarily putting intact male dogs at risk.
How it presents
Affected dogs typically show signs of urinary distress, such as blood in the urine, frequent straining, or difficulty urinating, usually starting between 1 and 4 years of age. A sudden, complete inability to urinate is a life-threatening emergency that requires immediate veterinary care.
Treatment
Management is lifelong and involves a specialized diet, preventative medication, and potentially surgery to remove stones, with typical costs ranging from 1,500 to 6,000 EUR. For this hormone-dependent variant, neutering male dogs can also significantly reduce the risk of stone formation.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cystinuria Type 3 Variant 2 risk factor?
This is an inherited metabolic disorder of the kidneys where the organ fails to properly reabsorb the amino acid cystine from the urine. Excess cystine then builds up and forms painful crystals or stones in the bladder and urinary tract. This specific Type 3 variant is complex and influenced by hormones, primarily putting intact male dogs at risk.
How is Cystinuria Type 3 Variant 2 risk factor tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Affenpinscher.