Cystinuria(Cyst-1a)
Also known as: Cystinurie Typ I-A · Cystine Urolithiasis · SLC3A1-associated cystinuria · Cystin-Harnsteine · Cystinuria Type I-A · …
Overview
What it is
Cystinuria is an inherited metabolic disorder affecting the kidneys, where the body fails to reabsorb an amino acid called cystine. Instead of being filtered back into the bloodstream, cystine builds up in the urine. Over time, this high concentration causes the amino acid to crystallize, forming painful stones in the bladder and urinary tract.
How it presents
Owners typically notice signs of urinary discomfort, such as straining to urinate, blood in the urine, or frequent attempts to go. These symptoms usually appear between 1 and 5 years of age, with male dogs being at a higher risk for life-threatening urinary blockages due to their anatomy.
Treatment
While the underlying genetic defect cannot be cured, the condition is manageable through lifelong special diets and medication to prevent stone formation. If a blockage occurs, emergency surgery is required, with overall treatment and management costs typically ranging from €2,000 to €12,000.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Cystinurie DNA-Test(CY)
Primary testDNA testDer DNA-Test identifiziert Mutationen in den Genen SLC3A1 und SLC7A9, die für den fehlerhaften Transport von Cystin in den Nieren verantwortlich sind.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
11 of 11 breeds
Mandatory testLandseerMandated by Verein von Landseerfreunden und -züchtern in Deutschland e.V. (VLD)
Mandatory testNewfoundland
RecommendedAmerican Bully
RecommendedAustralian Stumpy Tail Cattle Dog
RecommendedBullmastiff
RecommendedContinental Bulldog
RecommendedDeerhound
RecommendedKromfohrländer
RecommendedMastiff
RecommendedOld English Bulldog
RecommendedShikoku
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cystinuria?
Cystinuria is an inherited metabolic disorder affecting the kidneys, where the body fails to reabsorb an amino acid called cystine. Instead of being filtered back into the bloodstream, cystine builds up in the urine. Over time, this high concentration causes the amino acid to crystallize, forming painful stones in the bladder and urinary tract.
How is Cystinuria tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Cystinurie DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Landseer, Newfoundland, American Bully, Australian Stumpy Tail Cattle Dog, Bullmastiff, Continental Bulldog, Deerhound, Kromfohrländer.