Cystinuria, type III
Also known as: Cystinuria Type III · Androgen-dependent cystinuria · Cystinurie Typ III · Type III Cystinuria · Cystine urolithiasis Type III · …
Overview
What it is
Cystinuria type III is an inherited metabolic kidney disorder where the kidneys fail to reabsorb the amino acid cystine, which is a building block of proteins, back into the bloodstream. Instead, this substance accumulates in the urine, where it can crystallize. These crystals eventually clump together to form painful stones within the bladder or kidneys.
How it presents
Owners typically notice symptoms in adult dogs, particularly males, which include blood in the urine, straining to urinate, or frequent urination. If a stone completely blocks the flow of urine, it becomes a life-threatening emergency requiring immediate veterinary attention.
Treatment
The underlying defect is lifelong and cannot be cured, but it can be managed with a special diet, medication, and sometimes surgical stone removal. The lifetime cost of management and potential surgeries typically ranges from €1,500 to €7,000.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
2 of 2 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Cystinuria, type III?
Cystinuria type III is an inherited metabolic kidney disorder where the kidneys fail to reabsorb the amino acid cystine, which is a building block of proteins, back into the bloodstream. Instead, this substance accumulates in the urine, where it can crystallize. These crystals eventually clump together to form painful stones within the bladder or kidneys.
How is Cystinuria, type III tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Bulldog, Affenpinscher.