Central core myopathy(CCM)
Also known as: Central Core Disease · CCD · Zentralkern-Myopathie · Zentralkernmyopathie · RYR1-Myopathie · …
Overview
What it is
Central core myopathy in Great Danes is an inherited muscle disorder that is now classified as a form of Centronuclear Myopathy (CNM). It is caused by a mutation in the BIN1 gene, which disrupts the internal structure of skeletal muscle cells and prevents them from contracting normally. This structural defect leads to generalized muscle weakness and dysfunction across the body.
How it presents
Symptoms typically appear during puppyhood or early youth. Owners will notice significant muscle weakness, rapid fatigue during mild exercise, and a stiff, awkward, or wobbly way of walking.
Treatment
There is no cure for this condition, meaning treatment is lifelong and focuses on supportive care, physiotherapy, and pain management. The expected lifetime cost for supportive veterinary care ranges from 1,500 to 6,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Central core myopathy?
Central core myopathy in Great Danes is an inherited muscle disorder that is now classified as a form of Centronuclear Myopathy (CNM). It is caused by a mutation in the BIN1 gene, which disrupts the internal structure of skeletal muscle cells and prevents them from contracting normally. This structural defect leads to generalized muscle weakness and dysfunction across the body.
How is Central core myopathy tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.