Canine cyclic hematopoiesis(GCS)
Also known as: Gray Collie Syndrome · Grey Collie Syndrome · Cyclic Neutropenia · Canine Cyclic Neutropenia · Graues Collie-Syndrom · …
Overview
What it is
This is an inherited bone marrow disorder where the body's production of blood cells, particularly infection-fighting white blood cells, drops drastically at regular intervals. This cyclic drop temporarily leaves the dog's immune system highly vulnerable to infections. The condition is caused by a genetic mutation affecting how stem cells in the bone marrow mature.
How it presents
Affected puppies are typically recognizable by a distinct silver-grey coat and begin showing symptoms in early puppyhood. Every 10 to 12 days, as their white blood cell count drops, they experience recurring bouts of fever, lethargy, joint pain, and infections.
Treatment
There is no cure for this condition, and management requires lifelong, intensive supportive care, including frequent antibiotics and medical therapies during low-cell phases. The estimated cost for managing this severe condition ranges from 2,000 to 8,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Zyklische Neutropenie (GCS) DNA-Test(GCS)
Primary testDNA testEin DNA-Test, der die ursächliche Mutation im AP3B1-Gen nachweist, um betroffene Hunde und Anlageträger sicher zu identifizieren.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Canine cyclic hematopoiesis?
This is an inherited bone marrow disorder where the body's production of blood cells, particularly infection-fighting white blood cells, drops drastically at regular intervals. This cyclic drop temporarily leaves the dog's immune system highly vulnerable to infections. The condition is caused by a genetic mutation affecting how stem cells in the bone marrow mature.
How is Canine cyclic hematopoiesis tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Zyklische Neutropenie (GCS) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: American Collie, Border Collie, Rough Collie, Shetland Sheepdog, Smooth Collie.