Bleeding disorder, P2RY12-related(P2RY12)
Also known as: P2RY12-related platelet dysfunction · P2RY12 thrombopathia · Thrombozytopathie (P2RY12) · Platelet receptor P2RY12 defect · P2RY12-Defekt · …
Overview
What it is
This is an inherited blood clotting disorder affecting the circulatory system, specifically the blood platelets (thrombocytes). A genetic defect in the P2RY12 receptor prevents these platelets from clumping together properly to form clots. As a result, the dog's body cannot efficiently stop bleeding after an injury or blood vessel damage.
How it presents
Symptoms are typically first noticed during puppyhood, often starting during teething or after minor injuries. Owners may observe prolonged bleeding from small cuts, frequent nosebleeds, or unexplained bruising.
Treatment
The condition is lifelong and cannot be cured, but it can be managed by avoiding rough play and trauma. Emergency treatments or support during necessary surgeries, such as blood transfusions, typically cost between 500 and 3,500 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
P2Y12-Rezeptor-Defekt DNA-Test(P2Y12)
Primary testDNA testEin Gentest identifiziert die Mutation im P2RY12-Gen, die fuer den Defekt des ADP-Rezeptors auf den Thrombozyten verantwortlich ist und zu einer gestoerten Blutgerinnung fuehrt.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Bleeding disorder, P2RY12-related?
This is an inherited blood clotting disorder affecting the circulatory system, specifically the blood platelets (thrombocytes). A genetic defect in the P2RY12 receptor prevents these platelets from clumping together properly to form clots. As a result, the dog's body cannot efficiently stop bleeding after an injury or blood vessel damage.
How is Bleeding disorder, P2RY12-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), P2Y12-Rezeptor-Defekt DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.