Spinocerebellar ataxia, SPTBN2-related(NCCD)
Also known as: Neonatal Cerebellar Cortical Degeneration · Spinocerebellar Ataxia Beagle type · SPTBN2-related cerebellar ataxia · Cerebellar Cortical Degeneration
Overview
What it is
This is an inherited neurological disorder that causes the progressive breakdown of nerve cells in the cerebellum, which is the area of the brain responsible for coordinating movement. As these cells degenerate, the brain can no longer properly control muscle coordination and balance.
How it presents
Symptoms typically appear in puppies just a few weeks after birth. Owners will notice a wobbly gait, frequent loss of balance, and a general lack of coordination that rapidly worsens.
Treatment
There is no cure for this condition, and management is limited to diagnostic testing and supportive care, with costs typically ranging from 300 to 1000 EUR. Because the disease progresses quickly and severely impacts quality of life, humane euthanasia is often necessary during puppyhood.
How it's tested
NCCD (Neonatal Cerebellar Cortical Degeneration) DNA-Test(NCCD)
Primary testDNA testEin molekularbiologischer DNA-Test zum Nachweis der ursächlichen Mutation im SPTBN2-Gen bei Hunden.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Spinocerebellar ataxia, SPTBN2-related?
This is an inherited neurological disorder that causes the progressive breakdown of nerve cells in the cerebellum, which is the area of the brain responsible for coordinating movement. As these cells degenerate, the brain can no longer properly control muscle coordination and balance.
How is Spinocerebellar ataxia, SPTBN2-related tested?
Tests currently in our database: NCCD (Neonatal Cerebellar Cortical Degeneration) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.