Spinocerebellar ataxia, SLC12A6-related(SCA)
Also known as: Spinocerebellar Ataxia SLC12A6-related · SLC12A6-SCA · Spinocerebelläre Ataxie (SLC12A6) · SLC12A6 hereditary ataxia
Overview
What it is
This is a hereditary neurological disorder caused by a genetic mutation that disrupts the normal function of nerve cells in the brain and spinal cord. Specifically, it leads to the progressive degeneration of the cerebellum, which is the part of the brain responsible for coordinating movement. As these nerve cells break down, the dog loses the ability to control its limbs and balance properly.
How it presents
Affected puppies typically begin showing signs of coordination loss, such as an unsteady, swaying gait and frequent stumbling, at just a few months of age. These balance issues and uncontrolled movements steadily worsen as the dog grows.
Treatment
There is no cure for this progressive condition, and management is focused entirely on supportive care and comfort. Lifetime costs for diagnostic confirmation and palliative care generally range from 500 to 2000 EUR, though early euthanasia is often chosen to prevent suffering.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Spinocerebellar ataxia, SLC12A6-related?
This is a hereditary neurological disorder caused by a genetic mutation that disrupts the normal function of nerve cells in the brain and spinal cord. Specifically, it leads to the progressive degeneration of the cerebellum, which is the part of the brain responsible for coordinating movement. As these nerve cells break down, the dog loses the ability to control its limbs and balance properly.
How is Spinocerebellar ataxia, SLC12A6-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.