SETX-related ataxia
Also known as: Senataxin-associated ataxia · SETX cerebellar ataxia · Spinocerebellar ataxia SETX-type · SETX-related progressive abnormal gait
Overview
What it is
This is an inherited neurological disorder affecting the nervous system, caused by a genetic mutation in the SETX gene. This defect leads to the progressive breakdown of nerve cells that are responsible for controlling and coordinating voluntary movements. As these cells degenerate, the brain loses its ability to properly communicate with the muscles.
How it presents
Owners typically notice symptoms in puppies or young adults, starting with an unsteady, wobbly gait and difficulty balancing. Over time, these coordination issues worsen and may be accompanied by visible muscle tremors.
Treatment
There is no cure for this progressive condition, and treatment is limited to supportive care to maintain quality of life. Managing symptoms and obtaining diagnostic confirmation typically costs between 500 and 2500 EUR.
How it's tested
SETX-Ataxie Gentest(SETX)
Primary testDNA testDieser Gentest identifiziert Mutationen im SETX-Gen, die für die erbliche Ataxie verantwortlich sind, um betroffene Hunde und Anlageträger frühzeitig zu erkennen.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is SETX-related ataxia?
This is an inherited neurological disorder affecting the nervous system, caused by a genetic mutation in the SETX gene. This defect leads to the progressive breakdown of nerve cells that are responsible for controlling and coordinating voluntary movements. As these cells degenerate, the brain loses its ability to properly communicate with the muscles.
How is SETX-related ataxia tested?
Tests currently in our database: SETX-Ataxie Gentest.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.