HACE1-related ataxia
Also known as: HACE1 ataxia · HACE1-assoziierte Ataxie · Cerebellar ataxia HACE1-related · Hereditary ataxia (HACE1-related) · Hereditary ataxia in Norwegian Elkhounds
Overview
What it is
HACE1-related ataxia is an inherited neurological disorder caused by a genetic mutation that leads to progressive damage in the cerebellum, which is the part of the brain responsible for coordinating movement. Without a properly functioning cerebellum, the brain cannot accurately control the muscles, leading to a loss of voluntary motor coordination.
How it presents
Owners typically notice symptoms during puppyhood or adolescence, starting with a wobbly gait, balance issues, and uncoordinated movements. Over time, these signs steadily worsen and may progress to noticeable tremors and difficulty standing.
Treatment
There is no cure for this progressive condition, and management is limited to supportive care to maintain quality of life. Supportive therapies typically cost between 500 and 3000 EUR, though early euthanasia is often considered due to the severity of the disease.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is HACE1-related ataxia?
HACE1-related ataxia is an inherited neurological disorder caused by a genetic mutation that leads to progressive damage in the cerebellum, which is the part of the brain responsible for coordinating movement. Without a properly functioning cerebellum, the brain cannot accurately control the muscles, leading to a loss of voluntary motor coordination.
How is HACE1-related ataxia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.