RALGAPA1-related cerebellar ataxia
Also known as: RALGAPA1 ataxia · Cerebellar ataxia RALGAPA1-related · Juvenile-onset cerebellar ataxia RALGAPA1 · RALGAPA1-assoziierte zerebelläre Ataxie
Overview
What it is
Cerebellar ataxia (CA1) is an inherited neurological disease that affects the brain, specifically the cerebellum, which is the area responsible for coordinating movement and balance. A genetic mutation in the RALGAPA1 gene causes the cells in this part of the brain to progressively degenerate. This degeneration leads to a gradual loss of voluntary muscle control.
How it presents
Owners will typically notice signs of uncoordinated movement, such as a clumsy or swaying gait, loss of balance, and head tremors. These symptoms usually first appear during puppyhood or adolescence and steadily worsen over time.
Treatment
There is no cure for this progressive condition, and supportive care is the only option to manage symptoms. Diagnostic testing and palliative care typically cost between 500 and 2000 EUR, though the severity of the disease often leads to early euthanasia.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is RALGAPA1-related cerebellar ataxia?
Cerebellar ataxia (CA1) is an inherited neurological disease that affects the brain, specifically the cerebellum, which is the area responsible for coordinating movement and balance. A genetic mutation in the RALGAPA1 gene causes the cells in this part of the brain to progressively degenerate. This degeneration leads to a gradual loss of voluntary muscle control.
How is RALGAPA1-related cerebellar ataxia tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.