Neonatal Cerebellar Ataxia (GRM1-related)(BNAt)
Also known as: Bandera's Neonatal Ataxia · Neonatal Cerebellar Ataxia · GRM1-related ataxia · Coton de Tulear cerebellar ataxia
Overview
What it is
This is an inherited neurological disorder that affects the cerebellum, which is the part of the brain responsible for coordinating movement. A genetic mutation in the GRM1 gene disrupts normal chemical signaling between brain cells from birth. This disruption prevents the brain from properly controlling muscle movements and balance.
How it presents
Symptoms typically become noticeable when puppies first attempt to walk, around two to three weeks of age. Owners will observe severe tremors, a profound lack of coordination, and an inability to stand or walk.
Treatment
There is no cure for this condition, and veterinary care—typically costing between 150 and 500 EUR—is focused on supportive evaluation. Because of the severe impact on the puppy's quality of life, humane euthanasia is usually the most compassionate option.
How it's tested
Bandera's Neonatal Ataxia (BNAt) DNA-Test(BNAt)
Primary testDNA testEin molekularbiologischer Gentest identifiziert die ursächliche Mutation im GRM1-Gen mittels einer DNA-Probe (Blut oder Backenabstrich).
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Neonatal Cerebellar Ataxia (GRM1-related)?
This is an inherited neurological disorder that affects the cerebellum, which is the part of the brain responsible for coordinating movement. A genetic mutation in the GRM1 gene disrupts normal chemical signaling between brain cells from birth. This disruption prevents the brain from properly controlling muscle movements and balance.
How is Neonatal Cerebellar Ataxia (GRM1-related) tested?
Tests currently in our database: Bandera's Neonatal Ataxia (BNAt) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.