Juvenile to adolescent cerebellar ataxia, RAB24-related(CA-RAB24)
Also known as: RAB24-related cerebellar ataxia · Juvenile cerebellar ataxia · Cerebellar cortical degeneration · RAB24 ataxia · Juvenile-onset cerebellar ataxia
Overview
What it is
This is an inherited neurological disease affecting the cerebellum, which is the part of the brain that controls balance and movement coordination. A genetic mutation in the RAB24 gene causes the nerve cells in this region to progressively break down and die. As these cells degenerate, the dog loses the ability to coordinate its physical movements.
How it presents
Owners typically notice symptoms like a swaying gait, loss of balance, and clumsy, uncoordinated movements starting between 6 months and 2 years of age. These coordination issues worsen progressively over time as the disease advances.
Treatment
There is no cure for this progressive condition, and supportive care is focused on maintaining comfort. Managing the disease and obtaining diagnostic confirmation typically costs between 1,000 and 3,000 EUR. Because of the severe and progressive nature of the disease, euthanasia is often eventually elected to prevent suffering.
How it's tested
RAB24-Gentest (Zerebelläre Ataxie)(CA-RAB24)
Primary testDNA testEin DNA-Test zum Nachweis der ursächlichen Mutation im RAB24-Gen, die für die juvenile zerebelläre Ataxie verantwortlich ist.
Issuing body: other
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Juvenile to adolescent cerebellar ataxia, RAB24-related?
This is an inherited neurological disease affecting the cerebellum, which is the part of the brain that controls balance and movement coordination. A genetic mutation in the RAB24 gene causes the nerve cells in this region to progressively break down and die. As these cells degenerate, the dog loses the ability to coordinate its physical movements.
How is Juvenile to adolescent cerebellar ataxia, RAB24-related tested?
Tests currently in our database: RAB24-Gentest (Zerebelläre Ataxie).
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.