Alpha-1-antitrypsin deficiency(AATD)
Also known as: Alpha-1-Antitrypsin-Mangel · AAT deficiency · Alpha-1 protease inhibitor deficiency · A1ATD
Overview
What it is
This condition is a deficiency of alpha-1-antitrypsin, a protective protein that normally stops the body's own enzymes from breaking down healthy tissues. Without enough of this protein, the enzymes cause progressive damage to the liver. A clinical serum test is used to confirm the diagnosis by measuring the level of this protein in the blood.
How it presents
Owners typically notice signs of liver disease, such as a loss of appetite, vomiting, yellowing of the skin and gums, and a swollen belly from fluid buildup. These symptoms usually begin to appear gradually during middle age.
Treatment
There is no cure, but the condition can be managed lifelong with a specialized diet, liver-protective supplements, and supportive therapies. Lifetime management costs typically range from 1,500 to 6,000 EUR.
How it's tested
Bestimmung der Alpha-1-Antitrypsin-Konzentration im Serum(AAT-Serumtest)
Primary testClinical examDer Test misst die Konzentration oder Aktivität von Alpha-1-Antitrypsin im Blutserum mittels ELISA oder Proteinelektrophorese, um einen angeborenen Mangel bei chronischen Lebererkrankungen nachzuweisen.
Issuing body: vet
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Alpha-1-antitrypsin deficiency?
This condition is a deficiency of alpha-1-antitrypsin, a protective protein that normally stops the body's own enzymes from breaking down healthy tissues. Without enough of this protein, the enzymes cause progressive damage to the liver. A clinical serum test is used to confirm the diagnosis by measuring the level of this protein in the blood.
How is Alpha-1-antitrypsin deficiency tested?
Tests currently in our database: Bestimmung der Alpha-1-Antitrypsin-Konzentration im Serum.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.