Alanine aminotransferase, reduced activity(ALT)
Also known as: Reduced ALT activity · Alanine Aminotransferase Deficiency · GPT gene variant · Low baseline ALT · Alanine Aminotransferase Activity Variant
Overview
What it is
This is not a disease, but rather a harmless genetic variation that causes lower activity of alanine aminotransferase (ALT), an enzyme primarily found in the liver. Because ALT levels are typically measured to screen for liver damage, knowing a dog has this variant is important for veterinarians. A seemingly normal ALT reading in these dogs could actually mask an underlying liver issue that would otherwise show up as elevated.
How it presents
Dogs with this variant do not show any clinical symptoms or health impairments at any age. The trait is only detected through routine veterinary blood tests that show unusually low baseline liver enzyme levels.
Treatment
No treatment is required as this is a harmless physiological variation. There are no associated medical or therapeutic costs, resulting in a lifetime cost of 0 EUR.
How it's tested
Alanin-Aminotransferase (ALT) Aktivität Gentest(ALT-Aktivität)
Primary testDNA testEin Gentest identifiziert die Mutation im GPT-Gen, die eine verringerte Grundaktivität des Leberenzyms Alanin-Aminotransferase verursacht, damit Tierärzte Blutwerte richtig interpretieren können.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Alanine aminotransferase, reduced activity?
This is not a disease, but rather a harmless genetic variation that causes lower activity of alanine aminotransferase (ALT), an enzyme primarily found in the liver. Because ALT levels are typically measured to screen for liver damage, knowing a dog has this variant is important for veterinarians. A seemingly normal ALT reading in these dogs could actually mask an underlying liver issue that would otherwise show up as elevated.
How is Alanine aminotransferase, reduced activity tested?
Tests currently in our database: Alanin-Aminotransferase (ALT) Aktivität Gentest.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.