Addison’s disease and multiple autoimmune syndrome, RESF1-related
Also known as: RESF1-related autoimmune syndrome · Addison's disease and multiple autoimmune syndrome · Autoimmunsyndrom Typ Addison · Canine multiple autoimmune syndrome · RESF1-assoziiertes Autoimmunsyndrom · …
Overview
What it is
This is an inherited autoimmune disorder where the dog's immune system mistakenly attacks its own healthy organs, particularly the adrenal glands. This leads to Addison's disease, a condition where the adrenal glands fail to produce essential hormones needed to regulate hydration and stress. In Nova Scotia Duck Tolling Retrievers, this specific RESF1-associated condition is known as Juvenile Addison's Disease (JADD).
How it presents
Symptoms typically appear in young dogs and include chronic weakness, vomiting, diarrhea, weight loss, and sudden collapse-like episodes. Owners may notice these signs fluctuating or worsening during times of stress.
Treatment
While the condition is incurable, it is manageable through lifelong hormone replacement therapy and regular veterinary monitoring. The lifetime cost of managing this severe condition typically ranges from 5,000 to 15,000 EUR.
How it's tested
RESF1-assoziierter Morbus Addison und multiples Autoimmunsyndrom DNA-Test(RESF1)
Primary testDNA testDer genetische Test identifiziert die Mutation im RESF1-Gen, welche für die Entstehung von Morbus Addison und dem multiplen Autoimmunsyndrom verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Addison’s disease and multiple autoimmune syndrome, RESF1-related?
This is an inherited autoimmune disorder where the dog's immune system mistakenly attacks its own healthy organs, particularly the adrenal glands. This leads to Addison's disease, a condition where the adrenal glands fail to produce essential hormones needed to regulate hydration and stress. In Nova Scotia Duck Tolling Retrievers, this specific RESF1-associated condition is known as Juvenile Addison's Disease (JADD).
How is Addison’s disease and multiple autoimmune syndrome, RESF1-related tested?
Tests currently in our database: RESF1-assoziierter Morbus Addison und multiples Autoimmunsyndrom DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.