Achromatopsia-3, CNGB3-related(ACHM)
Also known as: Day Blindness · Cone Degeneration · CNGB3-ACHM · Tagblindheit · Zapfendegeneration · …
Overview
What it is
Achromatopsia-3 is an inherited eye disorder affecting the retina, which is the light-sensitive tissue at the back of the eye. It is caused by a genetic mutation that prevents the cone photoreceptors—the cells responsible for detecting bright light—from functioning properly. Consequently, affected dogs experience severely impaired vision in bright daylight, while their vision remains normal in dim light.
How it presents
Symptoms typically become noticeable in puppies between 8 and 12 weeks of age. Owners may observe their dog squinting, avoiding bright sunlight, or bumping into obstacles during the day, while navigating normally at night.
Treatment
While the condition is incurable, it is painless and does not worsen over time. Lifelong management, such as using specialized tinted dog goggles for outdoor activities, typically costs between 200 and 1000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Achromatopsie (ACHM) DNA-Test(ACHM)
Primary testDNA testEin DNA-Test analysiert das CNGB3-Gen auf die spezifische Mutation, die für Achromatopsie-3 (Tagblindheit) verantwortlich ist.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Achromatopsia-3, CNGB3-related?
Achromatopsia-3 is an inherited eye disorder affecting the retina, which is the light-sensitive tissue at the back of the eye. It is caused by a genetic mutation that prevents the cone photoreceptors—the cells responsible for detecting bright light—from functioning properly. Consequently, affected dogs experience severely impaired vision in bright daylight, while their vision remains normal in dim light.
How is Achromatopsia-3, CNGB3-related tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Achromatopsie (ACHM) DNA-Test, Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Alaskan Husky, Alaskan Malamute, German Shorthaired Pointer.