Myeloperoxidase deficiency(MPOD)
Also known as: MPO deficiency · Myeloperoxidase-Mangel · Congenital myeloperoxidase deficiency · Neutrophil myeloperoxidase deficiency · MPO-Mangel
Overview
What it is
This is an inherited immune system disorder where white blood cells lack myeloperoxidase, an essential enzyme used to kill invading microbes. Without this enzyme, the immune system's ability to destroy certain bacteria and fungi is reduced. This deficiency affects the dog's white blood cells, which are the body's primary defense against infection.
How it presents
Most affected dogs remain completely healthy and show no symptoms throughout their lives. In rare cases, owners might notice recurrent or persistent skin and mucosal infections, which can develop at any age.
Treatment
There is no cure for the underlying genetic deficiency, and most dogs do not require any treatment. If infections do occur, they are managed on an as-needed basis with targeted medications, with supportive care costs typically ranging from 200 to 1,500 EUR.
How it's tested
Myeloperoxidase-Defizienz (MPOD) DNA-Test(MPOD)
Primary testDNA testEin Gentest identifiziert die verantwortliche Mutation im MPO-Gen, um betroffene Hunde und Anlageträger frühzeitig und zuverlässig zu bestimmen.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Myeloperoxidase deficiency?
This is an inherited immune system disorder where white blood cells lack myeloperoxidase, an essential enzyme used to kill invading microbes. Without this enzyme, the immune system's ability to destroy certain bacteria and fungi is reduced. This deficiency affects the dog's white blood cells, which are the body's primary defense against infection.
How is Myeloperoxidase deficiency tested?
Tests currently in our database: Myeloperoxidase-Defizienz (MPOD) DNA-Test.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.