Degenerative Myelopathy Early-Onset Modifier (Pembroke Welsh Corgi)
Also known as: Early-Onset Degenerative Myelopathy Modifier · SP110 modifier · Pembroke Welsh Corgi DM Modifier · Frühzeitige Degenerative Myelopathie Modifikator · Corgi DM early-onset risk factor
Overview
What it is
This genetic modifier, abbreviated as DMRM, is a variation in the SP110 gene that accelerates the onset of Degenerative Myelopathy (DM) in Pembroke Welsh Corgis. DM is a severe, progressive disease of the spinal cord where the protective sheath around the nerves degrades, disrupting the signals between the brain and the body. Dogs carrying this modifier experience this neurological decline much earlier in life than those without it.
How it presents
Owners typically first notice weakness, unsteadiness, or wobbliness in the hind legs, which gradually progresses to dragging the paws and eventual paralysis. With this early-onset modifier, these symptoms often appear around 7 to 9 years of age.
Treatment
There is no cure for this condition, meaning treatment is lifelong and focuses on supportive care, physical therapy, and mobility aids. The estimated lifetime cost for managing this disease ranges from 2,000 to 8,000 EUR.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
1 of 1 breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is Degenerative Myelopathy Early-Onset Modifier (Pembroke Welsh Corgi)?
This genetic modifier, abbreviated as DMRM, is a variation in the SP110 gene that accelerates the onset of Degenerative Myelopathy (DM) in Pembroke Welsh Corgis. DM is a severe, progressive disease of the spinal cord where the protective sheath around the nerves degrades, disrupting the signals between the brain and the body. Dogs carrying this modifier experience this neurological decline much earlier in life than those without it.
How is Degenerative Myelopathy Early-Onset Modifier (Pembroke Welsh Corgi) tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
Most commonly affected: Pembroke Welsh Corgi.