NAPEPLD-related Leukoencephalomyelopathy(LEMP)
Also known as: Leukoenzephalomyelopathie · NAPEPLD-associated LEMP · NAPEPLD-LEMP · Canine Leukoencephalomyelopathy · Leukoencephalomyelopathy, NAPEPLD-related
Overview
What it is
This is an inherited, degenerative disease of the nervous system, specifically affecting the brain and spinal cord. It occurs when the protective myelin sheath—the insulating layer that surrounds nerve fibers to help transmit signals—is progressively destroyed. Without this protective coating, the nervous system cannot properly send messages to the rest of the body.
How it presents
Owners typically first notice symptoms between 1 and 3 years of age, starting with an unsteady, wobbly gait and general coordination issues. These movement difficulties progressively worsen over time as the disease damages more of the nervous system.
Treatment
There is no cure for this progressive condition, and treatment is limited to supportive and palliative care to maintain quality of life. Managing the disease typically costs between 500 and 2000 EUR, which covers diagnostic testing and comfort care until euthanasia becomes necessary.
How it's tested
Labogen Komplettpaket (rassespezifisch)(Labogen-Panel)
Primary testDNA testRassespezifisches DNA-Panel (Labogen / Laboklin) — bündelt alle relevanten Erbkrankheiten der Rasse in einem Test.
Issuing body: Labogen
Result scheme: Clear/Carrier/Affected
Feragen Komplettpaket (rassespezifisch)(Feragen-Panel)
DNA testRassespezifisches DNA-Panel (Feragen, Österreich) — gleiches Konzept wie Labogen.
Issuing body: Feragen
Result scheme: Clear/Carrier/Affected
Embark Breed + Health Panel(Embark)
DNA testUS-Anbieter; 250+ genetische Erkrankungen + Abstammung. Anerkennung in DE/AT variiert je nach VDH-Verein.
Issuing body: Embark
Result scheme: Clear/Carrier/Affected
MyDogDNA Panel(MyDogDNA)
DNA testGenoscoper-basiertes Panel (Mars Petcare). 200+ Erkrankungen + Rassenkomposition.
Issuing body: MyDogDNA
Result scheme: Clear/Carrier/Affected
Affected breeds
Treatment cost
Estimated range of typical treatment cost. Actual cost depends on severity, clinic and region.
Frequently asked
What is NAPEPLD-related Leukoencephalomyelopathy?
This is an inherited, degenerative disease of the nervous system, specifically affecting the brain and spinal cord. It occurs when the protective myelin sheath—the insulating layer that surrounds nerve fibers to help transmit signals—is progressively destroyed. Without this protective coating, the nervous system cannot properly send messages to the rest of the body.
How is NAPEPLD-related Leukoencephalomyelopathy tested?
Tests currently in our database: Labogen Komplettpaket (rassespezifisch), Feragen Komplettpaket (rassespezifisch), Embark Breed + Health Panel, MyDogDNA Panel.
Which breeds are most affected?
This condition isn't tied to a specific breed in our database.